33^rd World Pediatrics Conference

Biography

Biography: Meron Shimeles

Abstract

Background: Perinatal asphyxia is a serious clinical problem globally resulting in million deaths and an equal number of serious neurological consequences.

Objective: To assess short- and long-term neurodevelopmental outcomes of neonates with HIE.

Methods: Institution based cross sectional analytic study

Results: A total of 154 neonates were included on the study. 56.2% were male. Majority (57.8%) were delivered in health center and 23.8% in TASH. Of the neonates with asphyxia, 27.5% had stage 1 HIE; 50.3% stage 2 HIE and 22.2 % stage 3. In hospital mortality was 22.1%. Majority of deaths (66.7%) occurred in the first 72hrs. Severity of HIE was significantly associated with mortality. (P- Value= 0.00) Prolonged hospital stay > 7 days was seen in 36 (31.3%) neonates. Oxygen support was given for > 72hours to 35(28.2%) neonates.

Data for long term outcome was available for 95 neonates. Evidence of GDD was detected in 18.9% of neonates. Language development delay occurred in 27.1%. The occurrence of delay in language development was statistically associated with the severity of HIE and the presence of seizure in first week of life. 12.5% of neonates developed cerebral palsy. Epileptic seizure occurred in 10.4% of the cases. Occurrence of seizure in first week of life is associated with future development of Epilepsy. (P value= 0.00)

Conclusion and Recommendation: HIE is a very important cause of neonatal morbidity and mortality. The study showed significant number of neonates with moderate and severe HIE and few from mild HIE developed neurodevelopmental sequel. The study recommends the BLH NICU shall strength its potential to properly investigate, image and manage patients with HIE. Another prospective study assessing long term neurodevelopmental outcomes on neonates with HIE is recommended.