Miguel Maluf
Sao Paulo Federal University (UNIFESP), Brazil
Title: Patients with pediatric prostheses suffer from mismatch and early calcification, which causes a high number of reoperations
Biography
Biography: Miguel Maluf
Abstract
Background: Patients with pediatric prostheses suffer from mismatch and early calcification, which causes a high number of reoperations
Methods: Expandable Polyurethane Stent Valve – EPSV, is composed by flexible polyurethane (PU) cusps is grown on the top of an expandable cobalt-chrome alloy stent, including the formation of three leaflets. Physical, Hydrodynamic, Animal studies, were performed following: ISO 5840-3, 2015.
Results: Physical Tests. Result of study of surface scanning of pre and post crimp stent, showed no structural modification of the PU. Hydrodynamic test showed a pressure gradient oscillation between 5 to 20mm, in basal or stress conditions respectively. Experimental studies. Sheep were subjected to 3D echo-Doppler study, in 6th follow-up months, which showed satisfactory hemodynamic performance, with low transvalvular gradient (M = 6.60 mm Hg). Ultra structural Study: Six stents were explanted after 20 days to 21 months of follow-up to Ultra structural analysis. All of which revealed no presence of calcium growth and prostheses structure was intact.
Conclusions: Expandable Stent valve and PU no Calcification is good expectations for pediatric use.